What is NMN？

NMN, short for nicotinamide mononucleotide, is a precursor of a biological substance within the body that reduces with age. NMN is made from vitamin B3 and naturally produced in the body. Maintaining the level of intracellular NMN is believed to contribute to better general health and well being.

And since the biological substance in the body is an important molecule for maintaining a healthy body condition, it should be replenished as much as it is reduced, but th e biological substance is not absorbed as it is even if ingested by mouth, can not be used by the body. However, by ingesting NMN, a precursor of that biological substance, it is utilized for the body.

Curb the effects of aging by consuming NMN on a daily basis

NMN is found in breast milk and vegetables with high beta-carotene, such as broccoli, avocadoes, and green soybeans. However, the quantity found in these foods is extremely minimal. NMN is converted into NAD in the body, but this gradually decreases with age. In our late 50s, its quantity is nearly half of what it once was, and continues to decline thereafter. As a result, it becomes impossible to supplement it with food alone. Therefore, consuming NMN like a supplement is a means of curbing the onset of aging.

NAD, which is converted from NMN,
is known to decrease with aging.

NMN

When consuming NMN through the mouth,
it passes through NMN transporters on the cell surface and is absorbed into cells,
where it is converted into NAD.

NAD

NAD (nicotinamide adenine dinucleotide) can be found in the cells of every living organism,
and is the source of the body’s internal metabolism,
being used whenever energy is produced. However, NAD production begins to decrease in the body as we age.
Moreover, research has found that when consumed directly, NAD tends not to reach the cells, so consuming NMN,
a NAD precursor, is a more efficient means of delivering it to the body.
Attention is being drawn to NAD for its potential use in anti-aging using the two methods below.

Synthesis of energy (ATP) in the mitochondria

ATP refers to a source of energy that all living things use to survive. All eukaryotic cells and most archaebacteria and bacteria use NAD to synthesize ATP. NAD is essential to the synthesis of ATP; without it, living organisms die.

Sirtuin (SIRT) activation

The mechanisms behind aging hinge on an enzyme called sirtuin. This may be an unfamiliar term, but it is a protein that exists widely in organisms from bacteria to mammals, and plays a special role in controlling aging and lifespan. Humans possess a class of seven proteins called sirtuins that help control aging of the organs, but these sirtuins are normally dormant. NAD functions as a switch that acts on all seven of these sirtuins. In other words, as NAD declines through aging, the “switch” controlling sirtuins stops functioning, which is believed to contribute to decreased organ and tissue function.

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